Scientist, Precision Medicine

This job is right for you if you like:

  • High-energy start-ups, with a brilliant and passionate team
  • Solving problems that make a real difference in people’s lives and well being
  • Rapid growth and the ability to make a personal, directional impact on strategy/execution
  • Guiding innovative products, services, and processes from idea to user adoption
  • Rockstar teammates: an unparalleled team with decades of prior work experience in artificial intelligence, software systems, molecular biology, clinical oncology, clinical and regulatory operations, and related fields

About xCures

xCures helps patients and their doctors beat late stage and/or recalcitrant cancer. We operate an AI-assisted platform that provides highly-tailored, up-to-date information regarding the optimal (investigational or approved) therapies to consider in specific patient cases. In doing so, xCures’ platform prospectively generates real-world evidence for clinical studies and decentralized trials. xCures is founded by serial entrepreneurs and led by a management team with more than 10 successful combined exits under their belts. We are backed by Vanedge Capital Partners in a large seed round, are already bringing in meaningful revenue, and have now raised a Series A round in a rapid growth phase. This is an exciting time to join the company!

About the role

The Scientist, Precision Medicine is a highly motivated PhD-level scientist with training in molecular pharmacology, cancer biology, or a related life science field with a strong desire to impact clinical care. You have a strong handle on fundamental cancer biology principles and a deep interest in clinical research and cancer treatment modalities. Reporting to the VP of Scientific and Medical Affairs, you will help to build and maintain our knowledgebase of therapeutic options for cancer, supporting patients with the most promising treatment options and our business development team with detailed scientific and clinical research. You will help to codify treatment rationales from leading oncologists and perform real world data research integrating these datasets with outcomes data from our longitudinal patient registry.

Responsibilities

  • Research, identify, and characterize novel therapeutics and treatment regimens for advanced cancer patients
  • Review options recommendations from xCures algorithms, providing appropriate patient feature selection, options rankings, and rationale development
  • Annotate clinical data/metadata and therapeutic rationales for ingestion by xCures algorithms, including periodic updates based on new scientific literature and clinical trial results.
  • Provide medical review of real world data elements in xCures electronic data capture system
  • Conduct research on real-world data in the xCures registry, identifying cohorts of patients on emerging regimens and contributing to publications
  • Source novel treatment options and rationales from discussions with scientists, patients, and physicians
  • Support the business development arm with concise research on emerging therapeutics and companies
  • Optimize workflows across the Scientific and Medical Affairs team and author or revise Standard Operating Procedures (SOPs)

Requirements

  • Education
    • PhD in a Life Science field such as Molecular Biology, Genetics, or Systems Biology
  • Experience
    • 0-5 years of postdoctoral experience (academic or industry)
    • Significant experience with scientific and clinical literature; ability to quickly judge article quality and summarize the central message of scientific reports
    • Experience with clinical research and demonstrated ability to apply precision medicine principles
    • Strong publication record
    • Experience in start-ups, high-tech organizations, and/or entrepreneurial roles preferred
  • Skills, competencies, and capabilities
    • Deep knowledge of cancer biology/cell signaling and precision medicine / molecular pharmacology principles
    • Familiarity with large biological/chemical databases (TCGA, NCI thesaurus, DrugBank, ChEMBL, etc.)
    • Comfort manipulating, analyzing, and presenting findings from large and diverse intersecting datasets
    • Demonstrated ability to work independently with minimal supervision
    • Ability to adapt and thrive in a rapidly changing start-up environment, “wear many hats”
    • Outstanding work ethic and communication skills
    • Team player with an entrepreneurial mindset
    • Comfort working remotely with diverse teams to accomplish shared goals

Optional but preferred skills

  • Training and past experience applying Good Clinical Practices (GCP)
  • Experience with electronic data capture systems (EDCs)
  • Training in systems biology and experience with python, R, or related coding language 
  • Experience with SQL databases and business intelligence tools (Power BI, Tableau)
  • Experience with cloud computing, AWS

Notes

This is a big list. Don’t worry if you do not meet every qualification or wishlist item. If you are passionate, ambitious, adept, and mission-aligned, then we want to hear from you — even if you don’t check every box listed here. True talent shines through and transcends a list of bullet points.

Anticipated start date, August 1, 2021

To apply, send your resume and a note why you are interested to: tstuhlmiller@xcures.com