In this in-depth conversation, Dr. Colleen Lyons dives into the nuanced intersection of ethics and AI in healthcare, spotlighting overlooked risks and opportunities in today’s clinical AI tools. Drawing from her background at the FDA and in academia, she critiques the hollow nature of many "ethical AI" frameworks and calls for transparency and value-based governance over check-the-box compliance. The conversation covers the Belmont Report’s enduring relevance, AI's impact on autonomy and informed consent, and the systemic bias embedded in data. With regulatory landscapes still fragmented, Lyons argues for proactive, values-driven leadership to ensure AI adoption benefits patient care without unintended harms—particularly in vulnerable populations. If you're working at the frontline of AI implementation in provider systems or clinical operations, this episode is essential listening.