Frequently Asked Questions:

  • What is xDECIDE?

    xDECIDE is a clinical decision support tool that provides treatment decision support and patient case visualization via an online portal for oncologists and their staff.  Interactive online portals allow patients and their doctors to view a patient’s simplified graphical summary of their cancer history (Cancer Journey) and a patient’s personalized list of treatment options sourced from national expert oncologists (Options Report). We focus on patients with advanced cancer, and we have found promising options for many people with all types of cancers. Our approach has been to consider the most promising options for a patient and provide that information to the patient and doctor to discuss together. 

  • What does xDECIDE cost?

    We will not charge you or your patients to get an Options Report and/or Cancer Journey. Participation is granted through (de-identified) data. Sharing experiences with similar patients in the platform allows for collective learning from each other in real-time.

  • What is a Cancer Journey?

    Using the combined power of AI, predictive modeling, and natural language processing, the xCures platform transforms and compiles medical records, assembled from all institutions where a patient received prior care and tests, into a structured visual overview of their case history. This is called a Cancer Journey.

  • What is a Treatment Options Report?

    Once a Cancer Journey is created, it can be actively cross-referenced against xCures’ vast library of potential therapies, including novel or off-label treatments that go beyond standard of care and guidelines-based management, and even beyond clinical trial matching.

    The resulting Treatment Options Report is a rank-ordered set of treatments for consideration, with supporting medical rationales and information regarding therapy access. Option selection takes into account expert recommendations, insights from virtual tumor boards, public data sources, and an active learning network.

  • What will a Treatment Options Report look like?

    You can find an example of an xCures Options Report and Cancer Journey here.

  • How are the treatment rankings determined?

    Our advanced artificial intelligence (A.I.) technology matches patients with a personalized list of treatment options in 3 steps:

    1. Understanding the patient– xCures’ algorithms scan the medical records for distinctive traits to guide customized treatment. These include tumor type, genetic testing results, treatment history, other medical conditions, and more.

    2. Identify matching treatments – The xCures platform rigorously sifts through multiple sources of leading treatment data to match key traits from the medical records with the most relevant treatment options.

    Sources of data include:

    • Published research on which treatments work for similar patients, such as clinical trial results and case studies
    • Databases of treatments that match the patient’s distinctive genetic testing results
    • Outcomes from other patients on the xINFORM platform
    • Recommendations from doctors at leading academic medical institutions
    • Other scientific and medical databases

    3. Rank the best options – We rank the matching treatments by our best estimate of how well each could work for the patient. Our algorithms calculate these estimates based on matching with the information above, how often the treatment was recommended by experts to patients with similar traits, and also using data on similar patients who tried those treatments—either from our own platform or from published research.

    These outputs receive a final review by xCures’ PhD scientists, who collaborate with expert oncologists and leaders in the field in various tumor types, to provide a ranked options list with the medical and scientific reasoning behind each treatment.

  • What does xCures do to protect security?

    The security of your data is of paramount importance to xCures. It begins when you sign an informed consent form (ICF) allowing xCures to request information from your treating institutions under the Patient Right of Access (compliant with 45 CFR 164.524). Data is sent securely from the treating institutions to xCures, where it is stored in an Electronic Data Capture (EDC) system, compliant with 21 CFR Part 11. EDCs that are Part 11 compliant meet the FDA’s criteria for security and accuracy for tasks such as clinical trials and regulatory submissions. 

    Access to personally-identifiable health information (PHI) is restricted to the patient, their health care providers, and only those xCures employees who need access for their jobs (all such employees take training in handling PHI). Some xCures employees, such as software developers, who need access to the format of the data to but not the content, can access a version of data in which all PHI has been removed and replaced with tokens, so as to protect a patient’s privacy. 

    All data at rest within the system (e.g., in files, in databases, etc.) is encrypted. All data in motion (e.g., being viewed in a web browser, or sent via email) is likewise encrypted in transit. This is done to protect privacy at all times. Tools like CAPTCHAs are used to prevent attacks on web portals by malicious actors.  In addition, we provide security training to all xCures employees regarding best security practices, and we monitor our infrastructure for signs of intrusion or hacking attempts.