Frequently Asked Questions:

  • What is xINFORM?

    xINFORM is an oncology platform that provides advanced cancer patients with a personalized, data-driven and science-validated list of the most promising treatment options.

  • How does xINFORM work?

    xINFORM gathers and structures medical records to create your Cancer Journey.

    With the help of artificial intelligence (AI), a team of scientists sifts through current evidence,, to create a personalized Treatment Options Report. This report includes learnings from other cancer patients on the platform,  plus rationales for novel ways to access various therapies, from clinical trials to expanded access.

    To use xINFORM, patients must agree to provide their medical records and allow the platform to use their data to generate continuously improved options for other patients in the future.

    The video below shows how xINFORM takes patients’ medical information and delivers a treatment Options Report while allowing all the data acquired  to improve the evidence for future patients in a “perpetual trial.”

  • What is a Cancer Journey?

    Using the combined power of AI, predictive modeling, and natural language processing, the xCures platform transforms and compiles medical records, assembled from all institutions where a patient received prior care and tests, into a structured visual overview of their case history. This is called a Cancer Journey.

  • What is a Treatment Options Report?

    Once a Cancer Journey is created, it can be actively cross-referenced against xCures’ vast library of potential therapies, including novel or off-label treatments that go beyond standard of care and guidelines-based management, and even beyond clinical trial matching.

    The resulting Treatment Options Report is a rank-ordered set of treatments for consideration, with supporting medical rationales and information regarding therapy access. Option selection takes into account expert recommendations, insights from virtual tumor boards, public data sources, and an active learning network.

  • What will a Treatment Options Report look like?

    You can find an example of an xCures Options Report and Cancer Journey here.

  • How are the treatment rankings determined?

    Our advanced artificial intelligence (A.I.) technology matches patients with a personalized list of treatment options in 3 steps:

    1. Understanding the patient– xCures’ algorithms scan the medical records for distinctive traits to guide customized treatment. These include tumor type, genetic testing results, treatment history, other medical conditions, and more.

    2. Identify matching treatments – The xCures platform rigorously sifts through multiple sources of leading treatment data to match key traits from the medical records with the most relevant treatment options.

    Sources of data include:

    • Published research on which treatments work for similar patients, such as clinical trial results and case studies
    • Databases of treatments that match the patient’s distinctive genetic testing results
    • Outcomes from other patients on the xINFORM platform
    • Recommendations from doctors at leading academic medical institutions
    • Other scientific and medical databases

    3. Rank the best options – We rank the matching treatments by our best estimate of how well each could work for the patient. Our algorithms calculate these estimates based on matching with the information above, how often the treatment was recommended by experts to patients with similar traits, and also using data on similar patients who tried those treatments—either from our own platform or from published research.

    These outputs receive a final review by xCures’ PhD scientists, who collaborate with expert oncologists and leaders in the field in various tumor types, to provide a ranked options list with the medical and scientific reasoning behind each treatment.

  • How do I enroll in xINFORM?
    1. Go to 
    2. Provide your basic information:
      • name, email, phone number, zip code
      • date of birth
      • type of cancer
      • date of diagnosis 
    3. Provide your medical records. To generate your personalized cancer journey, we need to review and understand your medical history and records. The minimal medical records we need are:
      • the most recent clinic note detailing your treatment and medical history,
      • the most recent imaging/radiology (MRI/CT/PET, etc) reports,
      • all available pathology, molecular profiling, and genomic testing reports (Tempus, Caris, FoundationOne, etc).
    4. Sign the online participation agreement to provide “eConsent” to our terms of service.
      Your eConsent includes:
      • authorization to request medical records on your behalf. 
      • permission to use your (de-identified) data. Sharing your experiences with similar patients on the platform allows for collective learning from each other. When you agree to participate in our observational research protocol, you’re gaining access to information about the experiences of other patients and doctors as well as agreeing to share information about your experiences for their benefit

    The following video offers a detailed technical walkthrough of xINFORM registration. Any questions you have about registration are likely to be addressed here:

  • Why do I need to share my medical records?

    To generate your personalized Cancer Journey, we need to review and understand your medical history and records. The minimal medical records we need are:

    • The most recent clinic note detailing your treatment and medical history,
    • The most recent imaging/radiology (MRI/CT/PET, etc) reports,
    • All available pathology, molecular profiling, and genomic testing reports (Tempus, Caris, FoundationOne, etc).

    This will be the basis to generate your personalized Options Report. The more info you supply, the better the treatment options matching.

  • Are you HIPAA Compliant?

    We meet or exceed the physical, technical, and administrative security requirements of HIPAA and we continue to improve our ability to safeguard data and measure our state of compliance. For details, please read our Privacy Policy:

  • How do I share my medical records with you?

    To share your medical records you will need to do one of three things:

    1. The preferred method to share your records is to provide your medical portal credentials (login and password) via the xINFORM portal. This is highly recommended, as it is the fastest and safest way Or,
    2. Upload your medical records directly into xINFORM. Or,
    3. Give us the contact information of your treating physician(s) and institution(s) and we will request medical records on your behalf. Through this method, it may take between 2 to 6 weeks for us to receive your records
  • Why do I need to provide the name of my physician?

    Cancer is personal and the only way to find out what is good for you, is by reviewing your data.

    To get access to your medical records, we need to contact your physician’s office. It would be great if you could provide the office’s contact info as well, but we found many patients don’t know that. So we only really require the name of your physician and we’ll take care of the rest.

  • What does my doctor/care team need to provide?

    If you upload all the medical records we need, or share your medical portal credentials (MyChart or similar), your doctor/care team doesn’t have to provide anything – we can immediately start working on your Cancer Journey and Options Report. If not, and if requested, we will contact your doctor/care team for those records.

  • Will you contact my doctor/care team?

    Upon enrollment, we reach out to your doctor/team to let him/them know that you are participating in an observational research protocol and will be receiving a list of treatment options attained from evidence-based research. 

  • What does eConsent mean and how do I grant it?

    eConsent means that by electronically signing our online participation agreement, you accept the terms of our service. This includes authorization to request medical records on your behalf. When you agree to participate, you’re gaining access to information about the experiences of other patients and doctors as well as agreeing to share information about your experiences for their benefit.

  • How can I use the Options Report when working with my care team?

    When you get your options report and cancer journey, you can print them and take them to your oncologist. Also, these can be helpful when you’re seeing a new doctor who is unfamiliar with your case. 

    The options report and cancer journey can give you and your oncologist useful information and provide a snapshot of your treatment history. 

    In this short video, Rachel, a caregiver, talks about using the xINFORM reports in working with her husband’s care team. 

  • Does xINFORM cost me money?

    No. You participate with your (de-identified) data. Sharing your experiences with similar patients in the platform allows for collective learning from each other in real-time. Your information helps others, just as their information helps you. We will not charge you to get an Options Report and/or Cancer Journey.

  • How much time/effort does xINFORM require of me?

    The initial online form should take you less than 7 minutes. After that, it depends on how you give us access to your medical records. It is much quicker to give us access to your medical portal credentials (login and password) via the xINFORM portal. On the other hand, you can upload the records yourself, which may take some time to organize and upload.

  • What do I do with my Options Report and Cancer Journey?

    When you get your Options Report and Cancer Journey, you should print them and take them to your oncologist. This will allow you and your care team to discuss evidence-based, and data-driven information, chosen just for you. Your Cancer Journey and Options Report are especially helpful when you’re meeting a new doctor who is unfamiliar with your case. This report will ensure your oncologist doesn’t miss something that might be crucial for your next treatment. It also educates you and your caregivers about your history in a straightforward way. Remember, you are a member of your care team!

  • What do I do if my doctor and I decide to pursue an option from your report?

    We can assist your physician with access to non-standard of care treatments. For off-label treatments, we can work with your physician and/or treating institution to help with insurance reimbursement by providing scientific/clinical evidence to support an option. We can also support your physician in helping you with gaining access to options through Expanded Access Programs. If you decide to pursue a clinical trial, we can help with obtaining the contact information for the trial at a particular location closest to you.

  • What should I do if my condition changes and I need help again?

    Once you register for xINFORM, we are here to support you long-term. If your condition changes and you need our assistance, just reach out to us at We will work with you to obtain your most recent records as quickly as possible — if you provided your medical portal credentials, we will log in and download your recent records, or if you have them available, you can upload those records via your portal. Any additional information you can provide is also very helpful, such as when your next doctor’s appointment is or by when you need to make a decision regarding your treatment. We will then work diligently to generate an updated Cancer Journey and treatment Options Report for you

  • What does xCures do to protect security?

    The security of your data is of paramount importance to xCures. It begins when you sign an informed consent form (ICF) allowing xCures to request information from your treating institutions under the Patient Right of Access (compliant with 45 CFR 164.524). Data is sent securely from the treating institutions to xCures, where it is stored in an Electronic Data Capture (EDC) system, compliant with 21 CFR Part 11. EDCs that are Part 11 compliant meet the FDA’s criteria for security and accuracy for tasks such as clinical trials and regulatory submissions. 

    Access to personally-identifiable health information (PHI) is restricted to the patient, their health care providers, and only those xCures employees who need access for their jobs (all such employees take training in handling PHI). Some xCures employees, such as software developers, who need access to the format of the data to but not the content, can access a version of data in which all PHI has been removed and replaced with tokens, so as to protect a patient’s privacy. 

    All data at rest within the system (e.g., in files, in databases, etc.) is encrypted. All data in motion (e.g., being viewed in a web browser, or sent via email) is likewise encrypted in transit. This is done to protect privacy at all times. Tools like CAPTCHAs are used to prevent attacks on web portals by malicious actors.  In addition, we provide security training to all xCures employees regarding best security practices, and we monitor our infrastructure for signs of intrusion or hacking attempts.